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Osteoporosis is defined as a generalized decrease in bone mass (osteopenia) that affects bone matrix and mineral content equally, giving rise to fractures of vertebral bodies with bone pain, kyphosis, and shortening of the torso. Fractures of the hip and the distal radius are also common.
Reduction of testosterone to dihydrotestosterone occurs in most target organs; the latter possesses higher affinity for androgen receptors. Rapid intrahepatic degradation (plasma t1/2 ~ 15 min) yields androsterone among other metabolites (17-ketosteroids) that are eliminated as conjugates in the urine. Because of rapid hepatic metabolism, testosterone is unsuitable for oral use.

 

Penicillin G contains the basic structure common to all penicillins, 6-amino-penicillanic acid (p. 271, 6-APA), comprised of a thiazolidine and a 4-membered ?-lactam ring. 6- APA itself lacks antibacterial activity. Penicillins disrupt cell wall synthesis by inhibiting transpeptidase.
Rifampin is frequently given in combination with one or both of the following agents: Dapsone is a sulfone that, like sulfonamides, inhibits dihydrofolate synthesis (p. 272). It is bactericidal against susceptible strains of M. leprae. Dapsone is given orally. The most frequent adverse effect is methemoglobinemia with accelerated erythrocyte degradation (hemolysis).

 

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