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The drugs principally used are thiazides (possibly combined with K+-sparing diuretics) and loop diuretics. Prophylaxis of renal failure. In circulatory failure (shock), e. g. , secondary to massive hemorrhage, renal production of urine may cease (anuria). By means of diuretics an attempt is made to maintain urinary flow. Use of either osmotic or loop diuretics is indicated.
Activation of platelets, e. g. , upon contact with collagen of the extracellular matrix after injury to the vascular wall, constitutes the immediate and decisive step in initiating the process of primary hemostasis, i. e. , cessation of bleeding. However, in the absence of vascular injury, platelets can be activated as a result of damage to the endothelial cell lining of blood vessels. |
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